MicroRNA Biomarkers and VO2peak Variation in Older Adults
Author Information
Author(s): Karere Genesio, Hsu Fang-Chi, Cawthon Peggy, Zhang Xiping, Esser Karyn, Cox Laura, Kritchevsky Stephen
Primary Institution: Wake Forest University School of Medicine
Hypothesis
The study aims to identify microRNA biomarkers associated with variations in VO2peak among older adults.
Conclusion
The study identified potential circulating and tissue microRNA biomarkers related to VO2peak in older adults and the pathways associated with its variation.
Supporting Evidence
- Five serum miRNAs were identified that discriminate individuals with low or high VO2peak.
- In muscle, 14 miRNAs displayed differential expression in low and high VO2peak samples.
- Sex differences were found in the expression of 8 miRNAs in muscle.
- Ten differentially expressed miRNAs were predicted to regulate 50 other miRNAs.
- The top gene module correlated with VO2peak had a correlation coefficient of r=0.7.
Takeaway
Researchers looked at older adults to find tiny molecules in their blood that can help understand how fit they are based on their oxygen use during exercise.
Methodology
RNA sequencing was used to analyze serum and skeletal muscle samples from participants with varying VO2peak levels.
Participant Demographics
Participants were aged 70-91 years, with 53% being female.
Statistical Information
P-Value
4e-12
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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