Second Breast Cancers in Tuscany: Characteristics and Survival
Author Information
Author(s): S. Ciatto, N. Houssami, F. Martinelli, R. Bonardi, F. H. Cafferty, S. W. Duffy
Primary Institution: Centro per lo Studio e la Prevenzione Oncologica (CSPO), Istituto Scientifico della Regione Toscana, Florence, Italy
Hypothesis
What are the characteristics and prognosis of second breast cancers in women diagnosed in Tuscany?
Conclusion
The prognosis following a second breast cancer diagnosis in this cohort was generally good, with a 10-year survival rate of 78%.
Supporting Evidence
- Second cancers were more likely to be detected asymptomatically (67.0%).
- Estimated 10-year survival from a second cancer diagnosis was 78%.
- Survival was poorest when the second cancer was large or node-positive.
Takeaway
This study looked at women who had two breast cancers and found that most survived well, especially if the second cancer was small.
Methodology
Women with two breast cancer diagnoses were identified from histology records, and survival status was assessed using Cox regression analyses.
Potential Biases
Potential bias due to exclusion of women with metastatic cancer at the second diagnosis.
Limitations
Data on treatment were not available, and the study does not allow calculation of predictors of the occurrence of a second cancer event.
Participant Demographics
Women with a median age of 60 years at the second cancer diagnosis.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website