Quinolones for Treating Gonorrhea and Chlamydia
Author Information
Author(s): Sebastian Faro
Primary Institution: The University of Kansas School of Medicine
Hypothesis
Ofloxacin is an effective single-agent treatment for Neisseria gonorrhoeae and Chlamydia trachomatis infections.
Conclusion
Ofloxacin is effective in treating both gonococcal and chlamydial infections with a single oral dose.
Supporting Evidence
- Ofloxacin eradicated the gonococcus in 98% of the patients.
- Ofloxacin and doxycycline achieved cure rates of 99% and 95%, respectively.
- Ofloxacin is not affected by enzymes that confer resistance to tetracycline or penicillins.
Takeaway
Ofloxacin is a medicine that can help treat two common infections from sex, making it easier for doctors to help patients quickly.
Methodology
A multicenter study compared a single 400-mg dose of ofloxacin with a 3.0-g dose of amoxicillin or a 4.5-g dose of ampicillin plus probenecid.
Limitations
The study did not establish the efficacy of ofloxacin against anaerobic bacteria.
Participant Demographics
Patients with gonococcal and chlamydial infections, including those treated in STD clinics.
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