Impact of Genetic Variability on Cognitive Function in Preschoolers Exposed to DDT
Author Information
Author(s): Eva Morales, Jordi Sunyer, Francesc Castro-Giner, Xavier Estivill, Jordi Julvez, Nuria Ribas-Fitó, Maties Torrent, Joan O. Grimalt, Rafael de Cid
Primary Institution: Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Hypothesis
Genetic variability in glutathione S-transferase (GST) genes could influence the effects of prenatal exposure to p,p′-DDT on cognitive functioning.
Conclusion
Children with the GSTP1 Val-105 allele are at higher risk for adverse cognitive effects from prenatal p,p′-DDT exposure.
Supporting Evidence
- Children with GSTP1 Val-105 allele showed significant cognitive deficits associated with p,p′-DDT exposure.
- The study found no significant associations between p,p′-DDT and cognitive functioning for GSTM1 and GSTT1 polymorphisms.
- The research indicates that early-life exposure to p,p′-DDT is linked to decreased cognitive skills in preschoolers.
Takeaway
Some kids are more sensitive to the bad effects of a chemical called DDT because of their genes, which can make it harder for their brains to work well.
Methodology
The study used a prospective population-based birth cohort, assessing cognitive skills at age 4 and measuring organochlorine levels in cord serum.
Potential Biases
Potential exposure misclassification is assumed to be nondifferential.
Limitations
Selection bias may have occurred due to incomplete genotyping and exposure data for all eligible children.
Participant Demographics
Children from Menorca, Spain, with a mix of socioeconomic backgrounds.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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