Endocrine Treatment and Oestrogen Receptor Levels in Breast Cancer
Author Information
Author(s): E.D.C. Anderson, A.P.M. Forrest, P.A. Levack, U. Chetty, R.A. Hawkins
Primary Institution: University Department of Surgery, The Royal Infirmary, Edinburgh
Hypothesis
The response to endocrine treatment in breast cancer is related to the concentration of oestrogen receptors in the tumor.
Conclusion
Patients with higher oestrogen receptor concentrations had a significantly better response to endocrine therapy.
Supporting Evidence
- 60% of patients with ER concentrations > 20 fmol/mg responded to treatment.
- All patients who progressed had ER concentrations < 20 fmol/mg.
- The median ER concentration was lower in premenopausal patients compared to post-menopausal patients.
Takeaway
This study found that breast cancer patients with more oestrogen receptors in their tumors are more likely to respond well to hormone treatments.
Methodology
Patients received endocrine therapy for 3 months before surgery, and their tumor response was measured by changes in size.
Limitations
The study excluded patients over 70 and those with psychiatric issues or metastatic disease, which may limit generalizability.
Participant Demographics
17 premenopausal and 26 post-menopausal patients with operable breast cancer.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
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