Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders
Author Information
Author(s): Franceschin Ludovica, Guidotti Alessia, Mazzetto Roberto, Tartaglia Jacopo, Ciolfi Christian, Alaibac Mauro, Sernicola Alvise
Primary Institution: Dermatology Unit, Department of Medicine (DIMED), University of Padua, Italy
Hypothesis
The review analyzes current uses of therapeutic agents targeting neutrophil inflammation in dermatologic conditions.
Conclusion
Anti-neutrophilic drugs are versatile agents in treating various dermatological conditions and remain a cornerstone of dermatological therapy.
Supporting Evidence
- Neutrophils play a key role in both acute and chronic skin inflammation.
- Dapsone, colchicine, and tetracyclines are established drugs with anti-neutrophilic effects.
- Most uses of these drugs in neutrophil-mediated conditions are off-label and require further validation.
- Anti-neutrophilic drugs contribute significantly to managing complex skin conditions by modulating immune responses.
Takeaway
This study looks at old medicines that can help with skin problems caused by inflammation from neutrophils, which are a type of immune cell.
Methodology
The authors conducted a literature review by searching PubMed from inception to September 2024 for relevant papers in English.
Limitations
The review relies on existing literature, which may lack robust clinical trials for some off-label uses of the drugs discussed.
Digital Object Identifier (DOI)
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