Prognostic Value of uPAR in Oral Cancer
Author Information
Author(s): Bacchiocchi Roberta, Rubini Corrado, Pierpaoli Elisa, Borghetti Giulia, Procacci Pasquale, Nocini Pier Francesco, Santarelli Andrea, Rocchetti Romina, Ciavarella Domenico, Lo Muzio Lorenzo, Fazioli Francesca
Primary Institution: Polytechnic University of the Marche Region
Hypothesis
Can uPAR expression serve as a prognostic marker in oral squamous cell carcinoma (OSCC)?
Conclusion
uPAR may be a useful biomarker to identify higher risk subgroups of OSCC patients.
Supporting Evidence
- 39.1% of OSCC cases showed uPAR positivity.
- uPAR expression correlated with tumor differentiation grade.
- Patients with uPAR positive tumors had a lower life expectancy.
Takeaway
This study found that a protein called uPAR can help doctors understand which patients with oral cancer might be at higher risk for serious problems.
Methodology
The study analyzed uPAR expression in tissue samples from 189 OSCC patients using immunohistochemistry.
Potential Biases
Potential biases in histopathological evaluation and patient selection.
Limitations
The study is retrospective and may have biases related to sample selection.
Participant Demographics
143 males and 46 females, aged 33 to 95 years.
Statistical Information
P-Value
0.0053
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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