Using Cardiac MRI to Measure Heart Damage in Heart Attacks
Author Information
Author(s): Steffen Desch, Ingo Eitel, Suzanne Waha, Georg Fuernau, Philipp Lurz, Matthias Gutberlet, Gerhard Schuler, Holger Thiele
Primary Institution: University of Leipzig - Heart Center
Hypothesis
Can cardiac magnetic resonance imaging (CMR) parameters serve as reliable surrogate endpoints in clinical trials for acute myocardial infarction?
Conclusion
Cardiac magnetic resonance imaging provides valuable parameters that can be used as surrogate endpoints in clinical trials for acute myocardial infarction.
Supporting Evidence
- CMR can measure infarct size, myocardial salvage, and microvascular obstruction.
- Surrogate endpoints can reduce sample size and follow-up duration in clinical trials.
- CMR parameters have shown high reliability in measuring heart function and damage.
Takeaway
Doctors can use special heart scans to see how much damage a heart attack has done, which helps them understand how well treatments are working.
Methodology
The article reviews various CMR parameters and their validity and reliability as surrogate endpoints in myocardial infarction trials.
Potential Biases
There is a risk of bias in surrogate endpoints due to potential imbalances in baseline characteristics between treatment groups.
Limitations
Surrogate endpoints may lack validation studies and can underdiagnose rare adverse events due to smaller sample sizes.
Digital Object Identifier (DOI)
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