Mutations in the p53 Gene in Liver Cancer from Senegal
Author Information
Author(s): P. Coursaget, N. Depril, M. Chabaud, R. Nandi, V. Mayelo, P. LeCann, B. Yvonnet
Primary Institution: Institut de Virologie de Tours; Faculte de Medecine et de Pharmacie
Hypothesis
Is there a high prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal due to aflatoxin exposure?
Conclusion
The study found that 67% of liver cancer samples from Senegal had mutations at codon 249 of the p53 gene, indicating a strong association with aflatoxin exposure.
Supporting Evidence
- Mutation at codon 249 of the p53 gene was detected in 10 of the 15 tumour tissues tested.
- This frequency of mutation is the highest described.
- The study confirmed an association between high aflatoxin intake and high frequency of mutation in codon 249 of the p53 gene.
Takeaway
In Senegal, many people with liver cancer have a specific change in a gene called p53, which might be caused by eating moldy food.
Methodology
The study screened 15 liver cancer samples for mutations at codon 249 of the p53 gene using PCR and restriction analysis.
Limitations
The study only included a small sample size from one country, which may not represent the global situation.
Participant Demographics
All participants were Senegalese patients suffering from liver cancer.
Want to read the original?
Access the complete publication on the publisher's website