Effect of a Multicomponent Intervention on Acute Myocardial Infarction Diagnosis and Treatment in Tanzania: The MIMIC Implementation Trial
2024

Improving Heart Attack Care in Tanzania

Sample size: 852 publication Evidence: high

Author Information

Author(s): Hertz Julian Thornton, Nworie Joshua E, Shayo Frida M, Galson Sophie W, Coaxum Lauren, Daniel Ipyana, Makambay Patrick S, Akrabi Ally M, Manyangu Gloria J, Thielman Nathan M, Bloomfield Gerald S, Sakita Francis M

Hypothesis

The MIMIC intervention will improve the diagnosis and treatment of acute myocardial infarction in Tanzania.

Conclusion

The MIMIC intervention led to significant increases in the testing and treatment of acute myocardial infarction in a Tanzanian emergency department.

Supporting Evidence

  • ECG testing increased from 55.3% to 89.4% after the intervention.
  • Troponin testing increased from 41.4% to 78.0% after the intervention.
  • AMI case identification increased from 14.9% to 24.4% after the intervention.
  • Aspirin treatment increased from 34.4% to 71.6% among AMI participants after the intervention.
  • Clopidogrel treatment increased from 26.8% to 65.2% among AMI participants after the intervention.
  • Heparin treatment increased from 4.9% to 43.2% among AMI participants after the intervention.
  • Thirty-day survival rates among AMI participants did not significantly change.

Takeaway

This study shows that a new program helped doctors in Tanzania do a better job of finding and treating heart attacks.

Methodology

A single-arm pre-post trial was conducted with adults presenting with chest pain and/or dyspnea, comparing care before and after the MIMIC intervention.

Limitations

The study was conducted in a single emergency department, which may limit generalizability.

Participant Demographics

Adults presenting with chest pain and/or dyspnea in a Tanzanian emergency department.

Statistical Information

P-Value

<0.001

Confidence Interval

95% CI: 4.79-9.79

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.21203/rs.3.rs-5599267

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