How Skin Dendritic Cells Detect Protozoan Parasites
Author Information
Author(s): Ng Lai Guan, Hsu Alice, Mandell Michael A., Roediger Ben, Hoeller Christoph, Mrass Paulus, Iparraguirre Amaya, Cavanagh Lois L., Triccas James A., Beverley Stephen M., Scott Phillip, Weninger Wolfgang
Primary Institution: The Wistar Institute
Hypothesis
What is the behavior of dermal dendritic cells in response to protozoan parasites during infection?
Conclusion
The study reveals that migratory dermal dendritic cells can rapidly sense and engulf Leishmania parasites, transforming their behavior in response to infection.
Supporting Evidence
- Dendritic cells in the skin are highly motile and can rapidly respond to pathogens.
- Upon encountering Leishmania parasites, dendritic cells change from a migratory to a stationary state.
- Parasite uptake occurs through the extension of dynamic pseudopods by dendritic cells.
Takeaway
Skin cells called dendritic cells can move around and quickly find and eat tiny germs that get into the skin, helping to protect the body.
Methodology
The study used intravital two-photon microscopy to visualize the behavior of dendritic cells in the skin during infection with Leishmania major.
Digital Object Identifier (DOI)
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