Controlled Delivery of Gentamicin Using Poly(3-hydroxybutyrate) Microspheres
Author Information
Author(s): Francis Lydia, Meng Decheng, Knowles Jonathan, Keshavarz Tajalli, Boccaccini Aldo R., Roy Ipsita
Primary Institution: University of Westminster
Hypothesis
The study investigates the effects of various parameters on the characteristics of P(3HB) microspheres for controlled drug delivery of gentamicin.
Conclusion
The P(3HB) microspheres demonstrated high potential for controlled drug delivery, with an encapsulation efficiency of 48% and a bimodal release profile for gentamicin.
Supporting Evidence
- The average size of the microspheres was between 2 μm and 1.54 μm.
- Low stirring speeds produced larger microspheres compared to higher speeds.
- The encapsulation efficiency of gentamicin was found to be 48%.
- The in vitro release of gentamicin was bimodal, with an initial burst followed by sustained release.
- Microspheres showed high potential for biomedical applications.
Takeaway
Scientists made tiny balls from a special material that can hold medicine and release it slowly, which could help treat infections without causing side effects.
Methodology
P(3HB) microspheres were produced using a solid-in-oil-water technique, and their characteristics were analyzed based on varying polymer concentration, surfactant concentration, and stirring rates.
Limitations
The study does not address long-term stability and in vivo performance of the microspheres.
Digital Object Identifier (DOI)
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