Breast cysts and cancer risk
1991

Breast Cysts and Cancer Risk

Sample size: 644 publication Evidence: moderate

Author Information

Author(s): N.J. Bundred, R.R. West, J.O. Dowd, R.E. Mansel, L.E. Hughes

Primary Institution: University of Wales College of Medicine

Hypothesis

Is there an increased risk of breast cancer in women who have had a breast cyst aspirated?

Conclusion

Women who have had multiple breast cysts aspirated have an increased risk of breast cancer.

Supporting Evidence

  • 15 women developed breast cancer during the follow-up period.
  • 14 out of 352 women with aspirated cysts developed breast cancer, indicating a relative risk of 4.4.
  • Women with multiple cysts had the highest risk of developing breast cancer.

Takeaway

If a woman has had a breast cyst drained, she might have a higher chance of getting breast cancer, especially if she has many cysts.

Methodology

The study followed 644 women with benign breast nodularity from 1976 to 1982 to assess their subsequent breast cancer risk.

Potential Biases

Potential bias in tracing women and reliance on historical data.

Limitations

The study only included women who presented with benign nodularity and may not represent all women with breast cysts.

Participant Demographics

Women who presented with breast nodularity between 1976 and 1982.

Statistical Information

P-Value

p<0.001

Confidence Interval

95% confidence limits 1.6 and 4.8

Statistical Significance

p<0.001

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