Effects of Hispolon on Pain and Inflammation in Mice
Author Information
Author(s): Chang Heng-Yuan, Sheu Ming-Jyh, Yang Chun-Hung, Lu Tsung-Chun, Chang Yuan Shiun, Peng Wen-Huang, Huang Shyh-Shyun, Huang Guan-Jhong
Primary Institution: Institute of Chinese Pharmaceutical Sciences, Taichung, Taiwan
Hypothesis
Does hispolon have analgesic and anti-inflammatory effects in mice?
Conclusion
Hispolon significantly reduces pain and inflammation in mice, likely through antioxidant mechanisms.
Supporting Evidence
- Hispolon significantly inhibited acetic acid-induced writhing response in mice.
- Hispolon reduced formalin-induced pain in the late phase.
- Hispolon decreased paw edema induced by carrageenan.
- Hispolon increased antioxidant enzyme activities in liver tissue.
- Hispolon lowered levels of malondialdehyde in inflamed tissue.
Takeaway
Hispolon, a substance from a type of mushroom, helps reduce pain and swelling in mice.
Methodology
The study used acetic acid and formalin tests to measure pain response and carrageenan to induce inflammation in mice.
Limitations
The study was conducted only on male ICR mice, which may limit the generalizability of the results.
Participant Demographics
Male ICR mice, aged 6-8 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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