Metastatic Patterns of Lobular vs. Ductal Breast Carcinomas
Author Information
Author(s): A.R. Dixon, I.O. Ellis, C.W. Elston, R.W. Blamey
Primary Institution: City Hospital, Nottingham, UK
Hypothesis
Do invasive lobular and ductal carcinomas of the breast have different metastatic patterns?
Conclusion
Invasive lobular carcinoma has a distinct pattern of metastases and longer survival after metastasis compared to ductal carcinoma.
Supporting Evidence
- Lobular carcinoma showed significantly more hepatic and peritoneal metastases.
- Bilateral cancers were more common in the lobular group.
- Survival after metastasis was significantly longer in lobular carcinoma patients.
Takeaway
This study looked at two types of breast cancer and found that lobular cancer spreads differently and patients live longer after it spreads compared to ductal cancer.
Methodology
The study compared 77 patients with lobular carcinoma to 72 patients with ductal carcinoma, analyzing metastatic patterns and survival.
Limitations
The study did not include post-mortem studies to confirm metastatic sites.
Participant Demographics
Median age was 56 years for lobular and 54 years for ductal carcinoma patients.
Statistical Information
P-Value
0.01, 0.0003, 0.02
Statistical Significance
p<0.05
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