The Glucocorticoid Receptor: A Target for Toxins
Author Information
Author(s): Jeanette I. Webster, Esther M. Sternberg
Primary Institution: The Ohio State University Medical Center
Hypothesis
Can infectious agents and toxins affect glucocorticoid receptor function and contribute to glucocorticoid resistance?
Conclusion
An intact HPA axis and glucocorticoid release are essential for survival from toxic insults, and certain toxins can impair glucocorticoid receptor function.
Supporting Evidence
- Removal of the HPA axis or glucocorticoid receptor blockade increases mortality from various toxins.
- Replacement with synthetic glucocorticoids can reverse the lethal effects of toxins.
- Anthrax lethal toxin has been shown to repress glucocorticoid receptor function.
Takeaway
The body's stress response helps us survive infections and toxins, but some toxins can make this response less effective.
Methodology
The review discusses various studies on the effects of toxins on glucocorticoid receptor function and the implications for glucocorticoid therapy.
Limitations
The review primarily focuses on animal studies and may not fully translate to human conditions.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website