Protein and Amino Acid Supplementation and Muscle Atrophy
Author Information
Author(s): Jennifer A. Bunn, Thomas W. Buford, Monica C. Serra, Richard B. Kreider, Darryn S. Willoughby
Primary Institution: Baylor University
Hypothesis
Does protein and amino acid supplementation decrease muscle atrophy-related gene expression during immobilization?
Conclusion
Short-term immobilization increases muscle gene expression related to proteolysis, but protein and amino acid supplementation does not alter these effects.
Supporting Evidence
- All genes of interest increased over time, but there was no difference between groups.
- Lower-leg girth decreased over time, but there were no significant changes in body composition or strength.
- Increased expression of myostatin and TNF-α was observed during immobilization.
Takeaway
When you don't use your muscles for a while, your body starts to break them down, but taking extra protein doesn't help stop that from happening.
Methodology
Twenty males wore a lower-limb immobilization boot for 28 days and consumed either a protein and amino acid supplement or a carbohydrate placebo while their muscle was analyzed for gene expression.
Potential Biases
Potential bias in participant selection and dietary reporting.
Limitations
The study did not measure muscle atrophy directly and relied on gene expression as a proxy.
Participant Demographics
Twenty apparently healthy, recreationally active males aged 18-30.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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