Converting Effector T Cells into Graft-Protective Regulatory T Cells
Author Information
Author(s): Francis Ross, S Feng, G Tha-In, T Lyons, I S Wood, K J Bushell, A Bushell
Primary Institution: Nuffield Department of Surgery, University of Oxford
Hypothesis
Can transplantation tolerance induce the conversion of effector T cells into regulatory T cells?
Conclusion
The study shows that transplantation tolerance can convert potential effector T cells into graft-protective regulatory T cells.
Supporting Evidence
- Tolerance induction with anti-CD4+DST is dependent on CD25+ Treg.
- Tolerant mice accepted donor grafts indefinitely.
- Tolerant mice are enriched for graft-protective Treg.
- Tolerance induction inhibits CD4+ effector cell priming.
- Treg can develop from FOXP3− cells in vivo.
Takeaway
This study found that some immune cells can change their job from attacking a transplant to protecting it, which could help prevent organ rejection.
Methodology
Mice were treated with donor-specific transfusion and anti-CD4 antibodies to induce tolerance and assess T cell conversion.
Potential Biases
Potential bias in interpreting results from animal models to human applications.
Limitations
The study primarily used mouse models, which may not fully replicate human responses.
Participant Demographics
CBA (H2k) mice were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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