Stress Markers in Colectomy Patients
Author Information
Author(s): Theodor Asgeirsson, Sen Zhang, Sok Kean Khoo, James H. Resau, Nadav Dujovny, Anthony J. Senagore
Primary Institution: Spectrum Health Research
Hypothesis
This study evaluated the response of adiponectin, resistin, and sRAGE in colectomy patients with or without an enhanced recovery protocol.
Conclusion
Serum adiponectin, resistin, and sRAGE have the potential to develop into a panel of stress markers, with higher sRAGE levels indicating a protective role for colectomy recovery.
Supporting Evidence
- Adiponectin levels significantly decreased from PREOP to POD3.
- Resistin levels significantly increased from PREOP to POD1 and returned to baseline by POD3.
- sRAGE levels were significantly higher in LAP compared to HALS and OPEN.
Takeaway
Doctors looked at certain proteins in the blood of patients who had surgery to see how their bodies reacted to the stress of the operation.
Methodology
Serum samples were collected from 44 colectomy patients at three time points and analyzed using ELISA.
Potential Biases
Potential bias due to the random selection of patients and blinding to investigators.
Limitations
The study is limited by its sample size and the specific patient population.
Participant Demographics
Mean age was 59.7 years, with 26 males and 18 females.
Statistical Information
P-Value
P < 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website