Interactions between APP secretases and inflammatory mediators
Author Information
Author(s): Sastre Magdalena, Walter Jochen, Gentleman Steve M
Primary Institution: Imperial College London
Hypothesis
Determining the role of the different secretases involved in the generation of amyloid-β peptide (Aβ) is essential for understanding the regulation of inflammation in Alzheimer's disease (AD).
Conclusion
The review discusses the complex interactions between inflammatory mediators and APP secretases, suggesting that these interactions could provide therapeutic targets for Alzheimer's disease.
Supporting Evidence
- Aβ toxicity could be mediated through the induction of inflammatory events in the brain.
- Clinical investigations suggest that inflammatory changes in the AD brain are an early and prominent feature.
- Treatment with NSAIDs was associated with a reduced risk of developing AD.
Takeaway
This study looks at how inflammation and certain proteins in the brain interact in Alzheimer's disease, which could help find new ways to treat the disease.
Methodology
The review synthesizes existing literature on the interactions between APP secretases and inflammatory mediators in the context of Alzheimer's disease.
Limitations
The review is based on existing studies and does not present new experimental data.
Digital Object Identifier (DOI)
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