Effects of Antioxidant Cocktail on Eye Changes from Bed Rest
Author Information
Author(s): Kermorgant Marc, Varenne Fanny, Pavy-Le Traon Anne, Geeraerts Thomas, Barioulet Lisa, Fournié Pierre, Billette de Villemeur Rebecca, Bareille Marie-Pierre, Beck Arnaud, Golemis Adrianos, Antunes Inês, Gauquelin-Koch Guillemette, Soler Vincent, Quintyn Jean-Claude
Primary Institution: Institute for Space Medicine and Physiology (MEDES), Toulouse, France
Hypothesis
A thoraco-cephalic fluid shift induced by head-down bed rest will lead to ocular changes.
Conclusion
The study found that 60 days of head-down bed rest caused changes in eye health, but the antioxidant cocktail did not prevent these changes.
Supporting Evidence
- Two participants experienced peripapillary edema but recovered after 1 and 2 months.
- The antioxidant cocktail had minor impacts on the ophthalmological changes induced by head-down bed rest.
- Retinal nerve fiber layer thickness was preserved in all quadrants at recovery.
- Central retinal thickness tended to decrease after head-down bed rest.
Takeaway
When people lie down for a long time, their eyes can change, but taking vitamins didn't help fix those changes.
Methodology
Twenty healthy male subjects underwent a 60-day head-down bed rest, divided into two groups: one with an antioxidant cocktail and one without.
Potential Biases
Potential bias due to lack of a placebo control for the antioxidant cocktail.
Limitations
The study had a small sample size and only included male participants, limiting the generalizability of the findings.
Participant Demographics
Twenty healthy male subjects aged 34 ± 8 years.
Statistical Information
P-Value
p = 0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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