Genetic Links to Body Weight and Waist Size
Author Information
Author(s): Caroline S Fox, Nancy Heard-Costa, L Adrienne Cupples, Josée Dupuis, Ramachandran S Vasan, Larry D Atwood
Primary Institution: The National Heart Lung and Blood Institute's Framingham Heart Study
Hypothesis
We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study.
Conclusion
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip.
Supporting Evidence
- The study identified significant associations between SNPs and adiposity traits.
- Top SNPs associated with mean BMI and mean WC were identified.
- Replication of findings is necessary to confirm results.
Takeaway
This study looked at how certain genes might affect body weight and waist size in people. They found some genes that are linked to being overweight.
Methodology
Participants were genotyped with the Affymetrix 100K SNP GeneChip, and associations were evaluated using Generalized Estimating Equations (GEE) and Family Based Association Test (FBAT) models.
Potential Biases
Sample homogeneity may reduce population stratification but limits generalizability.
Limitations
The sample is not ethnically diverse or nationally representative, and none of the results reached genome-wide significance.
Participant Demographics
Participants were from the Framingham Heart Study, primarily of European descent.
Statistical Information
P-Value
1.22*10-7
Digital Object Identifier (DOI)
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