Extensively Drug-Resistant Tuberculosis in China
Author Information
Author(s): Tang Shenjie, Zhang Qing, Yu Jinming, Liu Yidian, Sha Wei, Sun Hua, Fan Lin, Gu Jin, Hao Xiaohui, Yao Lan, Xiao Heping
Primary Institution: Shanghai Pulmonary Hospital, Tongji University School of Medicine
Hypothesis
What is the prevalence of extensively drug-resistant tuberculosis (XDR TB) in China?
Conclusion
The study indicates that the prevalence of extensively drug-resistant tuberculosis (XDR TB) is a serious concern in China.
Supporting Evidence
- China has the second highest incidence of multidrug-resistant tuberculosis (MDR TB) worldwide.
- 30.0% of MDR strains were found to be extensively drug-resistant (XDR).
- 78.3% of MDR isolates were resistant to ofloxacin, which is higher than rates reported in South Korea and Taiwan.
- More than 90% of patients with XDR TB had strains resistant to multiple drugs.
Takeaway
This study found that a lot of tuberculosis cases in China are resistant to treatment, which makes it hard to help people get better.
Methodology
Patients with culture-proven MDR TB were retrospectively evaluated, and drug susceptibility testing was conducted using the BACTEC 960 System.
Limitations
The study was conducted in only one specialized TB hospital, making the data not representative of the general population.
Participant Demographics
All patients were HIV negative and had a history of TB treatment.
Digital Object Identifier (DOI)
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