Study of Acute Non-Haemolytic Transfusion Reactions in Patients
Author Information
Author(s): Shion Imoto, Nobuyuki Araki, Emiko Shimada, Kei Saigo, Koji Nishimura, Yoshihiro Nose, Yoshihiro Bouike, Masahiro Hashimoto, Hiroshi Mito, Hiroshi Okazaki
Primary Institution: Hyogo Red Cross Blood Center
Hypothesis
Is there a gender-related difference in acute non-haemolytic transfusion reactions (ANHTRs) and the relationship between antibodies in patients' and donors' sera?
Conclusion
The study found no significant association of ANHTRs with gender for both patients and donors, although anti-HLA antibodies were detected more frequently in females.
Supporting Evidence
- The positivity rate for anti-HLA antibodies was significantly higher in females (36%) compared to males (13%).
- Non-HLA antibodies were significantly associated with severe reactions in females.
- All TRALI cases had predisposing risk factors for acute lung injury.
Takeaway
This study looked at how blood transfusions affect men and women differently, but found that both groups had similar reactions.
Methodology
The study analyzed 223 ANHTR cases reported by 45 hospitals, screening for antibodies to HLA Class I, HLA Class II, granulocytes, and platelets.
Potential Biases
Potential bias due to the voluntary reporting system and the reliance on hospital records.
Limitations
The study was limited by the voluntary reporting of transfusion reactions and the retrospective nature of the data collection.
Participant Demographics
The study included 223 patients (92 females and 131 males) with a mean age of 54.2 years for females and 53.0 years for males.
Statistical Information
P-Value
0.00177
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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