FGF10/FGFR2 Signal Induces Cell Migration and Invasion in Pancreatic Cancer
Author Information
Author(s): Nomura S, Yoshitomi H, Takano S, Shida T, Kobayashi S, Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Miyazaki M
Primary Institution: The Department of General Surgery, Graduate School of Medicine, Chiba University
Hypothesis
Stromal cell–cancer cell interactions have an important role in the acquisition of aggressive characteristics by pancreatic cancer.
Conclusion
FGF10/FGFR2 signalling plays a significant role in promoting migration and invasion of pancreatic cancer cells, suggesting it as a potential target for new therapies.
Supporting Evidence
- Patients with high FGFR2 expression had a shorter survival time compared to those with low FGFR2 expression.
- FGF10 induced cell migration and invasion of pancreatic cancer cells through interaction with FGFR2-IIIb.
- FGF10 also induced expression of MT1-MMP and TGF-β1 mRNA in pancreatic cancer cells.
Takeaway
This study found that a signal from surrounding cells helps pancreatic cancer cells move and spread, which could lead to new treatments.
Methodology
The study involved immunostaining of pancreatic cancer tissues, cell migration and invasion assays, and analysis of gene expression.
Participant Demographics
76 pancreatic cancer patients who underwent curative surgical resection.
Statistical Information
P-Value
0.047
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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