Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid
2011
Improving Drug Solubility with Cyclodextrin
publication
Evidence: moderate
Author Information
Author(s): Domańska Urszula, Pelczarska Aleksandra, Pobudkowska Aneta
Primary Institution: Warsaw University of Technology
Hypothesis
The study investigates the effect of 2-hydroxypropyl-β-cyclodextrin on the solubility of sparingly soluble drug derivatives of anthranilic acid.
Conclusion
The study found that 2-hydroxypropyl-β-cyclodextrin significantly enhances the solubility of three drugs in aqueous solutions.
Supporting Evidence
- The solubility of drugs increased linearly with 2HP-β-CD concentration.
- The study determined stability constants for drug-cyclodextrin complexes.
- The highest solubility enhancement was observed for flufenamic acid at pH 2.
Takeaway
This study shows that a special sugar molecule can help some medicines dissolve better in water, making them easier to use.
Methodology
The study used phase solubility studies with UV-vis spectrophotometry to investigate the solubility of drug derivatives in the presence of 2HP-β-CD.
Digital Object Identifier (DOI)
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