PLOD1 as a Biomarker in Cancer
Author Information
Author(s): Zhai Zhao, Wang Shuo, Cao Yudong, Liu Jia, Zhao Qiang, Ji Yongpeng, Yang Xiao, Tang Xingxing, Ma Jinchao, Du Peng
Primary Institution: Peking University Cancer Hospital & Institute
Hypothesis
This study aims to elucidate the function and potential mechanism of action of PLOD1 across cancers.
Conclusion
PLOD1 is a potential oncogene and prognostic biomarker in pan-cancer, with high expression correlating with an immunosuppressive tumor microenvironment.
Supporting Evidence
- PLOD1 is upregulated in 24 of 33 cancer types compared to normal tissues.
- High PLOD1 expression is associated with poor overall survival in various cancers.
- PLOD1 expression correlates positively with immune cell infiltration in the tumor microenvironment.
Takeaway
PLOD1 is a protein that helps cancer cells grow and survive, and when it's too active, it can make cancer worse.
Methodology
The study used bioinformatics analysis of multiple databases and in vitro experiments to assess PLOD1's role in cancer.
Potential Biases
Potential systematic bias from reliance on multiple online databases.
Limitations
The study relied on bioinformatics analyses and in vitro experiments without large-scale patient cohort studies.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website