Ethyl 5,5-dichloro-3-(4-chlorophenyl)-3a-methyl-4a-phenyl-3a,4,4a,5-tetrahydro-3H-aziridino[2,1-d][1,2,4]triazolo[4,3-a][1,5]benzodiazepine-1-carboxylate
2011
Synthesis of New Benzodiazepine Derivatives
publication
Evidence: moderate
Author Information
Author(s): Boudina Aicha, Baouid Abdesselam, Driss Mohamed, Soumhi El Hassane
Primary Institution: Université Cadi Ayyad
Hypothesis
The study investigates the synthesis of new benzodiazepine derivatives through the addition of dichlorocarbene.
Conclusion
The crystallographic study confirmed the stereochemistry of the synthesized compound.
Supporting Evidence
- The compound was synthesized using dichlorocarbene and confirmed through crystallographic study.
- The study utilized various spectroscopic methods for structure elucidation.
- The reaction was carried out under phase transfer catalysis conditions.
Takeaway
The researchers made a new type of benzodiazepine by mixing certain chemicals, and they figured out how the new compound is shaped.
Methodology
The synthesis involved stirring [1,2,4]triazolo[4,3-a][1,5]benzodiazepine with dichlorocarbene under phase transfer catalysis conditions.
Digital Object Identifier (DOI)
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