Plumbagin Reduces Cancer Cell Invasion and Migration
Author Information
Author(s): Manu Kanjoormana, Aryan, Shanmugam Muthu K, Rajendran Peramaiyan, Li Feng, Ramachandran Lalitha, Hay Hui Sin, Kannaiyan Radhamani, Swamy Shivananju Nanjunda, Vali Shireen, Kapoor Shweta, Ramesh Bhargavi, Bist Pradeep, Koay Evelyn S, Lim Lina HK, Ahn Kwang Seok, Kumar Alan Prem, Sethi Gautam
Primary Institution: National University of Singapore
Hypothesis
Can plumbagin modulate CXCR4 expression and inhibit tumor cell invasion?
Conclusion
Plumbagin effectively downregulates CXCR4 expression and inhibits the migration and invasion of breast and gastric cancer cells.
Supporting Evidence
- Plumbagin downregulated CXCR4 expression in various tumor cell lines.
- Plumbagin inhibited CXCL12-induced migration and invasion of breast and gastric cancer cells.
- The downregulation of CXCR4 was not due to proteasomal degradation but occurred at the transcriptional level.
- Plumbagin suppressed NF-κB activation, which is linked to CXCR4 expression.
Takeaway
Plumbagin is a natural compound that helps stop cancer cells from moving and spreading by lowering a specific protein called CXCR4.
Methodology
The study used various assays including Western blot analysis, real-time PCR, and cellular migration and invasion assays to evaluate the effects of plumbagin on CXCR4 expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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