Biological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom
2010
Rosmarinic Acid as an Antidote for Snake Venom
Sample size: 8
publication
10 minutes
Evidence: high
Author Information
Author(s): Aung Hnin Thanda, Nikai Toshiaki, Komori Yumiko, Nonogaki Tsunemasa, Niwa Masatake, Takaya Yoshiaki
Primary Institution: Faculty of Pharmacy, Meijo University
Hypothesis
Can rosmarinic acid neutralize the hemorrhagic effects of Trimeresurus flavoviridis venom?
Conclusion
Rosmarinic acid effectively neutralizes the hemorrhagic effects of snake venom.
Supporting Evidence
- Rosmarinic acid inhibited hemorrhagic lesions in mice injected with snake venom.
- It protected human umbilical vein endothelial cells from venom toxicity.
- RA prevented the degradation of fibrinogen and type IV collagen by snake venom.
Takeaway
Rosmarinic acid can help stop bleeding caused by snake bites, making it a potential treatment.
Methodology
The study involved testing rosmarinic acid's effects on various snake venoms using assays on mice and cell cultures.
Limitations
The study primarily focused on specific types of snake venom and may not generalize to all snake bites.
Participant Demographics
ddY mice, average weight 20 g.
Digital Object Identifier (DOI)
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