Effects of Maximum Dose on Local Control After Stereotactic Body Radiotherapy for Oligometastatic Colorectal Cancer
Author Information
Author(s): Kang Su Jin, Park Jongmoo, Choi Gyu-Seog, Kim Jong Gwang, Park Jun Seok, Kim Hye Jin, Baek Jin Ho, Kang Byung Woog, Seo An Na, Park Shin-Hyung, Bae Bong Kyung, Kang Min Kyu, Park Soo Yeun
Primary Institution: Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Hypothesis
This study aimed to identify radiotherapy dosimetric parameters related to local failure-free survival in patients with lung and liver oligometastases from colorectal cancer treated with stereotactic body radiotherapy.
Conclusion
Increasing the maximum dose may be beneficial for managing larger tumors in patients with oligometastatic colorectal cancer.
Supporting Evidence
- LF occurred in 23.4% of the lesions.
- Lesions showing LF received significantly lower PTV D2 (146 ± 21 vs. 164 ± 23, p = 0.006).
- PTV D2 was the sole dosimetric parameter associated with LFFS.
Takeaway
Doctors found that giving a higher dose of radiation can help control larger tumors in patients with certain types of cancer that have spread.
Methodology
The study analyzed 75 oligometastatic lesions in 55 patients treated with SBRT, using dosimetric data calculated with Monte Carlo-based algorithms.
Potential Biases
The study may have biases related to the retrospective nature and exclusion criteria.
Limitations
The study is retrospective and may not capture all local failures due to limited follow-up.
Participant Demographics
The median age of participants was 71 years, with a male:female ratio of 35:20.
Statistical Information
P-Value
0.006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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