The Role of LDH Isoenzymes in Energy Metabolism
Author Information
Author(s): Bjørn Quistorff, Niels Grunnet
Primary Institution: The University of Copenhagen
Hypothesis
Does the isoenzyme pattern of lactate dehydrogenase (LDH) influence tissue lactate concentration during metabolic transitions?
Conclusion
The LDH isoenzyme pattern likely does not affect intracellular lactate concentration under steady state conditions, but may play a significant role during rapid metabolic transitions.
Supporting Evidence
- The LDH isoenzyme pattern does not influence tissue lactate concentration under steady state conditions.
- During rapid metabolic transitions, the isoenzyme pattern may significantly affect lactate concentration.
- Mathematical modeling suggests total LDH activity is more important than isoenzyme pattern.
Takeaway
LDH is an enzyme that helps convert lactate and pyruvate in our bodies. While it doesn't change how much lactate is in our cells all the time, it might help when our energy needs change quickly.
Methodology
The study involved a review of existing literature and mathematical modeling of the LDH reaction.
Limitations
The conclusions depend on whether the reported Km differences for pyruvate between LDH isoenzymes are present at physiological temperatures.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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