Discordant Results in Breast Cancer Receptor Testing
Author Information
Author(s): H. Helin, J. Isola, M. Helle, T. Koivula
Primary Institution: University of Tampere
Hypothesis
What are the reasons for discordant results between radioligand and immunohistochemical assays for steroid receptors in breast carcinoma?
Conclusion
The study found that discordant results between two types of receptor assays were common, particularly in premenopausal women and when receptor concentrations were low.
Supporting Evidence
- 18% of ER assays and 30% of PR assays showed discordant results.
- Immunohistochemistry-positive and steroid-binding-negative results were more common in discordant ER assays.
- Low binding affinity was significantly associated with discordant assay results.
Takeaway
This study looked at breast cancer tests and found that sometimes the results don't match up, especially in younger women. It helps doctors understand why this happens.
Methodology
The study analyzed surgical biopsy specimens using both steroid-binding and immunohistochemical assays to compare receptor statuses.
Potential Biases
Subjectivity in interpreting immunohistochemical results may introduce bias.
Limitations
The study did not account for all potential factors influencing assay results, such as tumor heterogeneity.
Participant Demographics
Median age of participants was 61 years, with 58 premenopausal and 121 postmenopausal women.
Statistical Information
P-Value
p<0.03
Confidence Interval
95% confidence limits
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website