Using MRI to Measure Heart Function and Dyssynchrony
Author Information
Author(s): Koos Ralf, Neizel Mirja, Schummers Georg, Krombach Gabriele A, Stanzel Sven, Günther Rolf W, Kelm Malte, Kühl Harald P
Primary Institution: Department of Cardiology, University Hospital RWTH Aachen, RWTH Aachen University
Hypothesis
Can cardiovascular magnetic resonance (CMR) effectively assess mechanical dyssynchrony in patients with reduced left ventricular (LV) function?
Conclusion
CMR with semi-automatic border detection may be useful for assessing mechanical dyssynchrony in patients with reduced LV function.
Supporting Evidence
- The mean SDI was significantly higher in patients with heart failure compared to controls (14 ± 5% vs. 5 ± 2%, p < 0.001).
- An exponential correlation between ejection fraction and SDI was observed (r = -0.84; p < 0.001).
- A significant association between SDI and the standard deviation of time to peak systolic motion of 12 LV segments was found (r = 0.66, p = 0.002).
Takeaway
This study looked at how well MRI can help doctors see if the heart is working together properly in patients with heart problems.
Methodology
The study involved 45 subjects, including 35 patients with reduced LV function and 10 healthy controls, using cine CMR and semi-automatic border detection to calculate the systolic dyssynchrony index (SDI).
Limitations
The study population was relatively small and did not assess the influence of infarct-related wall thinning on SDI calculation.
Participant Demographics
35 heart failure patients (22 men, average age 65 ± 8 years) and 10 healthy controls (average age 42 ± 21 years).
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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