Agreement Among Definitions of Metabolic Syndrome in Turkish Adults
Author Information
Author(s): Can Ahmet Selcuk, Bersot Thomas P
Primary Institution: Istanbul Science University, Faculty of Medicine
Hypothesis
The study aims to explore the agreement among various definitions of metabolic syndrome.
Conclusion
Definitions that do not require insulin measurement identify more patients with insulin resistance and higher cardiovascular risk scores than those that do.
Supporting Evidence
- The agreement between WHO and EGIR definitions was very good (kappa: 0.83).
- The age and sex adjusted prevalence of metabolic syndrome was 38% by NCEP and 19% by WHO definition.
- Definitions that do not require insulin measurement identified twice as many patients with insulin resistance.
- Insulin sensitivity was calculated using HOMA-IR.
- Subjects identified by IDF definition had higher Framingham risk scores than those without metabolic syndrome.
Takeaway
This study looked at different ways to define metabolic syndrome and found that some methods catch more people at risk for heart problems than others.
Methodology
Cross-sectional, methodological study evaluating cardiometabolic risk factors and agreement among definitions using kappa statistics.
Potential Biases
Potential bias due to exclusion of certain populations and reliance on self-reported data.
Limitations
The study is cross-sectional and relies on HOMA-IR for insulin sensitivity, which may not perfectly correlate with gold standard methods.
Participant Demographics
1568 subjects (532 men, 1036 women, mean age 45 years), with 67% from urban and 33% from rural areas.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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