JNK Signaling and Amyloid-ß in Alzheimer's Disease
Author Information
Author(s): Tare Meghana, Modi Rohan M., Nainaparampil Jaison J., Puli Oorvashi Roy, Bedi Shimpi, Fernandez-Funez Pedro, Kango-Singh Madhuri, Singh Amit
Primary Institution: University of Dayton
Hypothesis
How does Aß42 cause cell death in Drosophila models of Alzheimer's disease?
Conclusion
The study suggests that JNK signaling is activated by Aß42 and contributes to neurodegeneration in Alzheimer's disease.
Supporting Evidence
- Aß42 misexpression in Drosophila leads to increased cell death in the eye.
- Blocking JNK signaling significantly rescues neurodegenerative phenotypes.
- JNK signaling is activated in response to Aß42 accumulation.
Takeaway
This study shows that a protein linked to Alzheimer's disease can cause brain cell death in fruit flies, and blocking a specific signaling pathway can help protect those cells.
Methodology
The researchers used a Drosophila eye model to study the effects of Aß42 misexpression on cell death and JNK signaling.
Limitations
The study primarily uses a fruit fly model, which may not fully replicate human Alzheimer's disease.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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