Effects of Campomanesia xanthocarpa on Blood Clotting
Author Information
Author(s): Klafke Jonatas Zeni, Arnoldi da Silva Mariane, Fortes Rossato Mateus, Trevisan Gabriela, Banderó Walker Cristiani Isabel, Martins Leal Cláudio Alberto, Olschowsky Borges Diego, Chitolina Schetinger Maria Rosa, Noal Moresco Rafael, Medeiros Frescura Duarte Marta Maria, Soares dos Santos Adair Roberto, Nazário Viecili Paulo Ricardo, Ferreira Juliano
Primary Institution: Universidade Federal de Santa Maria
Hypothesis
The study investigates the antiplatelet, antithrombotic, and fibrinolytic activities of Campomanesia xanthocarpa extract.
Conclusion
Campomanesia xanthocarpa extract demonstrated significant antiplatelet, antithrombotic, and fibrinolytic activities in mice without causing cytotoxicity.
Supporting Evidence
- C. xanthocarpa extract inhibited ADP-induced platelet aggregation.
- The extract showed no cytotoxicity on platelets.
- C. xanthocarpa extract significantly reduced blood loss in treated mice.
- The extract did not induce ulcerogenic activity.
- C. xanthocarpa exhibited fibrinolytic activity in both mice and human blood.
Takeaway
This study shows that a plant called guavirova can help prevent blood clots and is safer than aspirin.
Methodology
Mice were treated with Campomanesia xanthocarpa extract and assessed for bleeding, thromboembolism, and platelet aggregation.
Limitations
The study primarily involved animal models, and human applicability needs further investigation.
Participant Demographics
Six healthy individuals aged approximately 30 years were included for in vitro assays.
Statistical Information
P-Value
p<0.05
Confidence Interval
15–84 μg/mL for EC50 of platelet aggregation
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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