Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding
1999
Monoclonal Origin of Multifocal Bladder Tumors
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Fadl-Elmula I, Gorunova L, Mandahl N, Elfving P, Lundgren R, Mitelman F, Heim S
Primary Institution: University Hospital, Lund, Sweden
Hypothesis
Do multifocal uroepithelial carcinomas arise from a monoclonal origin due to intraluminal seeding?
Conclusion
The study found that multifocal uroepithelial tumors likely originate from a single tumor through the shedding of cancer cells.
Supporting Evidence
- Karyotypically related clones were found in all informative tumours from each case.
- Rearrangement of chromosome 9 was seen in all cases.
- The presence of related clones indicates a monoclonal origin of multifocal tumors.
- Tumors may develop from cells shed from second primary tumors.
- The complex karyotypes suggest that seeding of tumor cells is a late event.
Takeaway
This study shows that bladder tumors can come from the same original tumor because cancer cells can spread inside the urinary tract.
Methodology
Cytogenetic analysis of 21 multifocal urinary tract transitional cell carcinomas from six patients.
Participant Demographics
Six patients with multifocal urinary tract transitional cell carcinomas.
Digital Object Identifier (DOI)
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