MicroRNA Profiles in Swine Muscle Development
Author Information
Author(s): Tara G McDaneld, Timothy P L Smith, Matthew E Doumit, Jeremy R Miles, Luiz L Coutinho, Tad S Sonstegard, Lakshmi K Matukumalli, Dan J Nonneman, Ralph T Wiedmann
Primary Institution: USDA/ARS Meat Animal Research Center
Hypothesis
The study aims to evaluate the role of microRNAs in the development of swine skeletal muscle.
Conclusion
The study identifies a complete set of microRNA transcriptome profiles that may play a vital role in muscle development and growth in swine.
Supporting Evidence
- Twelve potential novel microRNAs were detected that did not match previously reported sequences.
- Muscle-specific microRNA-206 was nearly absent in proliferating satellite cells but abundant at other stages.
- MicroRNA-1 was moderately abundant throughout development, peaking in adults.
- MicroRNA-133 was low in fetal development but increased in neonates and adults.
- Changes in microRNA abundance were observed across different developmental stages.
Takeaway
This study looks at tiny molecules called microRNAs that help muscles grow in pigs, showing how they change as the pigs develop.
Methodology
MicroRNA abundance was measured at various developmental stages in swine using cloning and sequencing methods.
Limitations
The study may not account for all variables affecting microRNA expression due to the complexity of muscle tissue.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website