Effect of 1 alpha-hydroxyvitamin D3 on rat liver cancer spread
Author Information
Author(s): T. Sato, K. Takusagawa, N. Asoo, K. Konno
Primary Institution: The Research Institute for Tuberculosis and Cancer, Tohoku University
Hypothesis
The study aims to examine the effect of 1 alpha-hydroxyvitamin D3 on metastases and survival time of tumor-bearing rats.
Conclusion
1 alpha-hydroxyvitamin D3 significantly inhibited lung and lymph node metastases and slightly prolonged the survival time of tumor-bearing rats.
Supporting Evidence
- 1 alpha-hydroxyvitamin D3 reduced the number of lung metastases from 8.7 to 3.2.
- The survival time increased from 24.8 days in the control group to 27.1 days in the treatment group.
- Primary tumor weight was slightly reduced in the treatment group.
Takeaway
This study found that a vitamin D treatment helped rats with liver cancer live a little longer and reduced the spread of their cancer.
Methodology
Rats were divided into two groups, one treated with 1 alpha-hydroxyvitamin D3 and the other with a control, and their tumor growth and survival were monitored.
Limitations
The study had a small sample size and the effects on primary tumors were not quantitatively assessed.
Participant Demographics
9- to 12-week old male ACI/N rats
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website