MTHFR C677T Polymorphism and Lung Cancer Risk in Koreans
Author Information
Author(s): Cui Lian-Hua, Shin Min-Ho, Kim Hee Nam, Song Hye-Rim, Piao Jin-Mei, Kweon Sun-Seog, Choi Jin-Su, Yun Woo-Jun, Kim Young-Chul, Oh In-Jae, Kim Kyu-Sik
Primary Institution: Chonnam National University Hwasun Hospital
Hypothesis
Is there an association between MTHFR C677T polymorphism and the risk of lung cancer in a Korean population?
Conclusion
The T allele of the MTHFR C677T polymorphism shows a weak protective association against lung squamous cell carcinoma.
Supporting Evidence
- The study involved 3938 lung cancer patients and 1700 healthy controls.
- MTHFR C677T frequencies were 34.5% CC, 48.5% CT, and 17% TT in lung cancer patients.
- The MTHFR 677 CT genotype showed a significantly decreased risk for squamous cell carcinoma.
- No significant interaction was found between MTHFR C677T polymorphism and smoking, gender, or age.
Takeaway
This study looked at whether a specific gene change affects the risk of lung cancer in Koreans, finding that one version of the gene might help protect against a certain type of lung cancer.
Methodology
A large-scale case-control study with 3938 lung cancer patients and 1700 healthy controls, using genotyping for MTHFR C677T polymorphisms.
Potential Biases
Potential bias due to the selection of cases from a hospital setting.
Limitations
The case group was composed of lung cancer patients from a hospital, which may not represent the general population.
Participant Demographics
3938 lung cancer patients and 1700 healthy controls, with a mean age of 64.8 years for patients and 52.2 years for controls.
Statistical Information
Confidence Interval
0.64-0.96 for squamous cell carcinoma risk with MTHFR 677 CT genotype.
Digital Object Identifier (DOI)
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