Relapse of tardive dyskinesia due to reduction in clozapine dose
2011
Clozapine and Tardive Dyskinesia
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Praharaj Samir Kumar
Primary Institution: Kasturba Medical College, Manipal, Karnataka, India
Hypothesis
Can clozapine treatment improve tardive dyskinesia symptoms?
Conclusion
Clozapine can improve tardive dyskinesia symptoms, but reducing its dose may cause symptoms to reemerge.
Supporting Evidence
- Clozapine improved tardive dyskinesia symptoms after 1 month of treatment.
- Symptoms reemerged when the clozapine dose was reduced from 200 mg to 150 mg.
- The patient has been stable on clozapine 200 mg/day for the last 20 months.
Takeaway
Clozapine can help with a condition called tardive dyskinesia, but if you take less of it, the problem might come back.
Methodology
The patient was treated with clozapine and monitored for changes in tardive dyskinesia symptoms.
Limitations
The study is based on a single case report.
Participant Demographics
One patient with tardive dyskinesia previously treated with fluphenazine.
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