Plasma vascular endothelial but not fibroblast growth factor levels correlate with colorectal liver metastasis vascularity and volume
2000
Plasma VEGF Levels and Colorectal Liver Metastasis
Sample size: 48
publication
Evidence: moderate
Author Information
Author(s): Davies M M, Jonas S K, Kaur S, Allen-Mersh T G
Primary Institution: Imperial College School of Medicine
Hypothesis
The study investigates the relationship between plasma levels of angiogenic factors and colorectal liver metastasis vascularity.
Conclusion
Higher plasma VEGF levels are associated with increased vascularity in colorectal liver metastasis.
Supporting Evidence
- There was a significant increase in plasma VEGF level in CLM patients compared to controls.
- Plasma VEGF levels correlated with tumour vessel count and volume.
- A high VEGF level predicted liver metastasis vascularity with good sensitivity and specificity.
Takeaway
This study found that a substance in the blood called VEGF can help predict how much blood supply a liver tumor has.
Methodology
Plasma VEGF and bFGF levels were measured in colorectal liver metastasis patients and controls using enzyme-linked immunosorbent assay.
Participant Demographics
29 colorectal liver metastasis patients and 19 healthy controls.
Statistical Information
P-Value
0.03
Confidence Interval
132.5–284.8 pg ml−1
Statistical Significance
p=0.03
Digital Object Identifier (DOI)
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