NT-proBNP Levels in Gestational Diabetes
Author Information
Author(s): Andreas Martin, Zeisler Harald, Handisurya Ammon, Franz Maximilian B, Gottsauner-Wolf Michael, Wolzt Michael, Kautzky-Willer Alexandra
Primary Institution: Medical University of Vienna, Austria
Hypothesis
Does NT-proBNP concentration differ in women with insulin dependent gestational diabetes mellitus compared to those with medical nutrition therapy alone?
Conclusion
NT-proBNP levels are lower in women with insulin dependent gestational diabetes mellitus compared to healthy controls.
Supporting Evidence
- NT-proBNP was significantly lower in patients with insulin dependent gestational diabetes mellitus compared to controls.
- Body mass index was higher in subjects with insulin dependent gestational diabetes compared to those with medical nutrition therapy.
- The study included a control group of women with normal glucose tolerance.
Takeaway
This study found that women with insulin dependent gestational diabetes have lower levels of a heart-related protein than healthy pregnant women.
Methodology
Measured NT-proBNP in 223 pregnant women with different severities of gestational diabetes between weeks 24 and 32.
Potential Biases
Potential for false negative interpretations of NT-proBNP results in insulin dependent gestational diabetes.
Limitations
Physiological cardiovascular changes during pregnancy were not considered.
Participant Demographics
223 pregnant women, including 90 with insulin dependent gestational diabetes and 45 with medical nutrition therapy.
Statistical Information
P-Value
0.012
Statistical Significance
p = 0.012
Digital Object Identifier (DOI)
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