Comparing Butoconazole and Miconazole for Vaginal Yeast Infections
Author Information
Author(s): Myra A. Lappin, Doris C. Brooker, Carol A. Francisco, Joan Dorfman
Primary Institution: San Francisco State University
Hypothesis
Is a 3-day treatment with butoconazole as effective as a 7-day treatment with miconazole for vulvovaginal candidiasis?
Conclusion
Both butoconazole and miconazole treatments were equally effective and well tolerated for vulvovaginal candidiasis.
Supporting Evidence
- Therapeutic cure rates were 57.8% for butoconazole and 61.4% for miconazole.
- Clinical cure rates at the first follow-up were 92.4% for butoconazole and 94.8% for miconazole.
- Microbiologic cure rates at the first follow-up were 88.1% for butoconazole and 89.6% for miconazole.
Takeaway
This study found that a shorter treatment with butoconazole works just as well as a longer treatment with miconazole for yeast infections.
Methodology
A multicenter, randomized, investigator-blind, parallel study comparing 3-day butoconazole and 7-day miconazole treatments in women with vulvovaginal candidiasis.
Limitations
The study may have been affected by the preponderance of patients with severe itching or burning in the butoconazole group.
Participant Demographics
Mean age 32 years, predominantly European (73%), with a range of 17-67 years.
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