Impact of Genetic Variants on Birth Weight and Glucose-Insulin Homeostasis in Asian Indians
Author Information
Author(s): Vasan Senthil K., Neville Matt J., Antonisamy Belavendra, Samuel Prasanna, Fall Caroline H., Geethanjali Finney S., Thomas Nihal, Raghupathy Palany, Brismar Kerstin, Karpe Fredrik
Primary Institution: Christian Medical College, Vellore, India
Hypothesis
Do genetic variants near CCNL1 and ADCY5 affect birth weight and glucose-insulin homeostasis in Asian Indians?
Conclusion
The study found that the low birth weight in Asian Indians is not explained by genetic variants near CCNL1 and ADCY5, but the ADCY5 variant is associated with elevated glucose levels and decreased insulin response.
Supporting Evidence
- The average birth weight in the population was 2.79±0.47 kg.
- Allele frequencies for the ‘birth weight-lowering’ variants were similar compared to Western populations.
- The ADCY5 variant was associated with increased fasting glucose and reduced insulin response.
- Participants with the ADCY5 variant had a higher risk of elevated glucose levels postprandially.
Takeaway
This study looked at whether certain genes affect birth weight and diabetes risk in Indian people. It found that while the genes didn't change birth weight, one of them did seem to affect blood sugar levels.
Methodology
The study genotyped 2,151 adults from a birth cohort for specific genetic variants and tested associations with birth weight and glycemic traits.
Potential Biases
The study may be affected by the high degree of consanguinity in the population, which could influence genetic associations.
Limitations
The study had limitations including a low number of diabetes cases and the inability to assess maternal genetic effects on birth weight.
Participant Demographics
Participants were adults aged 26-32 years, with a mix of rural (1,175) and urban (976) births.
Statistical Information
P-Value
0.027 for fasting glucose, 0.019 for 2-hour glucose, 0.050 for insulinogenic index, 0.010 for 2-hour insulin
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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