Deubiquitylating enzymes and disease
2008
Deubiquitylating Enzymes and Disease
publication
Evidence: moderate
Author Information
Author(s): Shweta Singhal, Matthew C Taylor, Rohan T Baker
Primary Institution: The Australian National University
Conclusion
Deubiquitylating enzymes (DUBs) play crucial roles in regulating cellular processes and have been implicated in various diseases, suggesting they are potential drug targets.
Supporting Evidence
- Some DUBs have been linked to human cancers, indicating their potential role in tumorigenesis.
- Mutations in DUBs can lead to altered expression levels and contribute to disease processes.
- Functional and structural information about DUBs is accumulating, which may facilitate drug development.
Takeaway
DUBs are special proteins that help control other proteins in our cells, and when they don't work right, it can lead to diseases like cancer.
Limitations
Many DUBs have not been well characterized, and their specific roles in diseases are still being investigated.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website