Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
2008
Sublethal RNA Oxidation and Neurodegenerative Disease
publication
Evidence: moderate
Author Information
Author(s): Rudy J. Castellani, Akihiko Nunomura, Raj K. Rolston, Paula I. Moreira, Atsushi Takeda, George Perry, Mark A. Smith
Primary Institution: University of Maryland
Hypothesis
RNA damage is involved in the pathogenesis of neurodegenerative diseases.
Conclusion
RNA oxidation is an early event in neurodegenerative diseases and may contribute to their progression.
Supporting Evidence
- Oxidative damage to RNA may cause errors in protein synthesis and gene expression.
- RNA oxidation has been observed in various neurodegenerative diseases including Alzheimer's and Parkinson's.
- Oxidized RNA is associated with disturbances in protein synthesis.
- RNA oxidation occurs early in the disease process, suggesting its role in disease initiation.
Takeaway
This study suggests that damage to RNA in our cells can lead to diseases like Alzheimer's and Parkinson's, and understanding this could help us find better treatments.
Methodology
The study reviews recent findings on RNA oxidation in neurodegenerative diseases and discusses its biological significance.
Digital Object Identifier (DOI)
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