Effects of Platinum Drugs on Nerve Toxicity
Author Information
Author(s): Screnci D, McKeage M J, Galettis P, Hambley T W, Palmer B D, Baguley B C
Primary Institution: The University of Auckland
Hypothesis
The differential toxicity of platinum drugs is due to differences in their partitioning into the peripheral nervous system.
Conclusion
The hydrophilicity of platinum drugs correlates with their accumulation in the peripheral nervous system but not with neurotoxicity.
Supporting Evidence
- Neurotoxicity was detected by measuring sensory nerve conduction velocity in Wistar rats.
- Tissue platinum concentrations were measured by inductively coupled plasma mass spectrometry.
- Ranking of the compounds by their neurotoxic potency in rats correlated with the frequency of neurotoxicity in patients.
- Log P correlated inversely with platinum accumulation in various nervous system tissues.
- Reactivity correlated with neurotoxicity potency in rats and with the frequency of neurotoxicity in patients.
Takeaway
This study looked at how different platinum drugs affect nerves. It found that how much of the drug gets into the nerves matters, but it doesn't always mean it will be toxic.
Methodology
Neurotoxicity was measured by sensory nerve conduction velocity in Wistar rats, and tissue platinum concentrations were measured using inductively coupled plasma mass spectrometry.
Participant Demographics
Wistar rats were used in the study.
Statistical Information
P-Value
P<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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