Mikkeli Osteoporosis Index Identifies Fracture Risk Factors
Author Information
Author(s): Waris Ville Juhana, Sirola Joonas P., Kiviniemi Vesa V., Tuppurainen Marjo T., Waris V. Pekka
Primary Institution: Mikkeli Central Hospital
Hypothesis
The study aims to develop a risk score that identifies both fracture risk factors and low bone mineral density (BMD) in the Finnish population.
Conclusion
The Mikkeli Osteoporosis Index (MOI) effectively identifies osteoporosis and fracture risk factors, aligning with FRAX intervention thresholds.
Supporting Evidence
- MOI identified femoral neck osteoporosis in development and validation cohorts.
- MOI showed good correlation with FRAX fracture risk assessment.
- The study included a large sample size of 500 fracture patients for analysis.
Takeaway
The Mikkeli Osteoporosis Index helps doctors figure out who is at risk for weak bones and fractures using a simple score.
Methodology
The study used two development cohorts and two validation cohorts, including fracture patients and population controls, to develop and validate the Mikkeli Osteoporosis Index.
Potential Biases
Potential bias due to differences in data collection methods between clinical and population cohorts.
Limitations
The study had a low participation rate among older fracture patients due to age and frailty, and the validation cohorts were geographically limited.
Participant Demographics
The study included Finnish postmenopausal women aged 45-79, with a focus on fracture patients and population controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website